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Creamy & Cozy Homemade Southern Chicken Spaghetti Casserole

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A delightful and comforting Southern casserole made with spaghetti, chicken, and cheese, perfect for weeknight dinners.

  • Total Time: 50 minutes
  • Yield: 6 servings 1x

Ingredients

Scale
  • 1 lb spaghetti noodles, broken in half
  • 2 cups cooked chicken, shredded or chopped
  • 1 can (10.5 oz) cream of mushroom soup
  • 1 can (10.5 oz) cream of chicken soup
  • 1 can (10 oz) diced tomatoes with green chilies
  • 2 cups shredded cheddar cheese, divided
  • 1 small onion, finely chopped
  • 1 tablespoon butter
  • ½ teaspoon garlic powder
  • Salt and pepper, to taste
  • ½ cup chicken broth or pasta water, if needed

Instructions

  1. Preheat your oven to 350°F (175°C).
  2. Boil the spaghetti noodles until al dente. Drain and set aside.
  3. In a skillet, melt the butter over medium heat. Add the chopped onion and cook until soft, about 3–4 minutes.
  4. In a large bowl, combine the cream of mushroom soup, cream of chicken soup, sautéed onion, diced tomatoes with chilies, garlic powder, and 1½ cups of cheese. Mix well.
  5. Stir in the shredded chicken and the cooked spaghetti. Add chicken broth or pasta water if the mixture is too thick.
  6. Transfer the mixture to a greased 9×13-inch baking dish. Top with the remaining cheese.
  7. Cover the dish with foil and bake for 25 minutes. Remove the foil and bake for another 10 minutes until bubbly and golden.
  8. Enjoy hot and cheesy straight from the oven!

Notes

This casserole pairs well with a fresh salad or warm crusty bread. Leftovers can be stored in the refrigerator for 3-4 days.

  • Author: nevaeh-hall
  • Prep Time: 15 minutes
  • Cook Time: 35 minutes
  • Category: Main Course
  • Method: Baking
  • Cuisine: Southern
  • Diet: Gluten-Free (with gluten-free pasta)

Nutrition

  • Serving Size: 1 serving
  • Calories: 450
  • Sugar: 4g
  • Sodium: 800mg
  • Fat: 20g
  • Saturated Fat: 10g
  • Unsaturated Fat: 8g
  • Trans Fat: 0g
  • Carbohydrates: 45g
  • Fiber: 3g
  • Protein: 25g
  • Cholesterol: 60mg